Perception Of Iron Deficiency Anemia (IDA) And Compliance Of Iron Supplements Among Pregnant Women Admitted To The Labor Ward At King Hussein Medical Centre, Amman, Jordan.

ABSTRACT 

Objective:  The main objective of our study was awareness of screening for iron deficiency anemia (IDA) among women adm itted to the labor ward at King Hussein Medical Centre (KHMC), Amman, Jordan.Their compliance with prescribed iron supplement and any side effects of treatment were also assessed.

Methods:  The data used in this study was collected from a cross-sectional survey primarily targeting patients admitted to the labor ward at KHMC, Amman during the period between February-August 2016. A total of 400 Women were interviewed. A questionnaire was filled after taking the consent of the woman.

Results: Anemia was as high as 40% at booking. Sixty-three percent of patients were not compliant with treatment.The most common two reasons for non-compliance were nausea (17%) and constipation (13%). More than half of those treated were still anemic at term.

Conclusion: Anemia is a common problem among our patients. We should have guidelines and protocols in place for the management of anemia in pregnancy.  More time should be allocated for explaining the risks of anemia, medications and the side effects to ensure compliance. Serum Ferritin should be measured routinely in all patients with low MCV to confirm the diagnosis of IDA.

Key Words: Perception, Anemia, screening, compliance, side-effect of treatment.

Our study concentrates on the following points:

· Is there screening for IDA during antenatal care? Are pregnant women being counseled about the benefits and the side effects of the iron supplement?

·  Do our pregnant women take their supplement on daily basis?

· Are they compliant with the treatment, and if not, why?

Materials and Methods

 The data collected for this study was collected from a cross-sectional survey primarily targeting patients admitted to the labor ward at King Hussein Medical Center during the period between February-August 2016. A total of 400 Women were interviewed.

A questionnaire was filled after the consent of the patient, (Figure 1).

It was completed by an Obstetrics and Gynecology resident. The questionnaire sought information about sociodemographic characteristics that included age, educational level for women, and area of residence.General obstetric characteristics including gravidity, parity, and birth weight were recorded, as were past obstetric history of anemia, its previous management and family history of anemia. There were questions regarding hemoglobin levels at booking and at delivery, most common symptoms of anemia, compliance with oral iron supplement sand any side –effects of treatment.

Patients were also asked about history of receiving intravenous iron or blood transfusion. Birth outcomes were also noted.

Fig1: Questionnaire sample.

Results

 Most of our patients were in the (25-29) year’s age group (39%), followed by (20-24) years age group (24%). (Chart I).

(Chart I ) : Age distribution in the studied sample

     Most of the women were primigravidas followed by the group of parity 1-2, (chart II).

(Chart II): Distribution of parity in the studied sample

  Thirty-five percent of our patients were university graduates and are employed.

Anemia was defined as less than 10g/dl was as high as 40% at booking. More than half of those patients continue to have anemia at term (25%). Less than one third of them reported anemia symptoms like dizziness, fatigue and general weakness.

Most of the women took oral iron supplements prescribed by doctors at the Royal Medical Services (RMS). Twenty-six percent of them took it more than once daily, (Chart III).

             (Chart III): frequency of iron supplementation in the studied                       sample.

Sixty-three percent of patients were not compliant with treatment.

The most common 2 reasons for non-compliance were nausea (17%) and constipation 13%.Thirty-seven percent of those reporting nausea discontinued therapy, (Table 1).

            Table (I)

One hundred and twenty women did not take any iron, (Chart III). Forty patients received at least 2 units of blood during their pregnancy or postpartum.15% of anemic mothers had low birth babies.80% of the women interviewed didn’t have counselling about the benefits and side effects of the supplement.

All patients had their Hb checked at booking and at delivery.

15% had another check when they presented with symptoms of anemia or bleeding.Almost all of the women received ferrous sulfate as oral iron supplement.

DISCUSSION

UP to 52% of pregnant women suffer from anemia in developing countries with great impact on their quality of their lives. If not treated, it can cause maternal and fetal adverse out comes, [10].

In ourstudy, screening of hemoglobin level was done at booking visit which is in first trimester, and at delivery.Anemia was diagnosed in our patients if the HB is less than 10 g/dl. Ferritin levels were not requested routinely. MCV was noted in all patients. Recommendations for current practice in the UK are to assess the mother’s hemoglobin concentration at booking and at 28 weeks’ gestation (NICE 2008) and ensure there are systems in place to follow up abnormal results. [11]. this is difficult in our country as we do not have clear protocols and the antenatal care is not well established in the primary care system. We should implement guidelines to make sure that anemia among our patients is not missed.

Checking Hb in the third trimester is essential because the demand of iron increased to 7.5 mg/day. [12] [13][14]  this predisposes to postpartum iron deficiency, which is associated with decreased physical abilities , psychic disturbances including emotional instability, depression, stress, and reduced cognitive performance, [15] [16] [117].

In addition, mortality rate was higher in women with very low hemoglobin levels. Also, co-morbidities such as postpartum hemorrhage, acute kidney injury, and disseminated intravascular coagulation were higher in anemic mothers, [18]. It is estimated that close to 20% of maternal mortalities are directly linked to anemia and another 50% of maternal deaths are associated with anemia [19].Anemia is common among our patients but no mortalities were noted among the study group. Less than one third of our sample reported symptoms of anemia.

The World Health Organization (WHO) and Centers for Disease Control (CDC) technical consultation on the assessment of iron status at the population level concluded that Hb and ferritin were the most efficient combination of indicators for monitoring changes in the iron status of a population as a consequence of iron supplementation (WHO/CDC 2005) but in our study the diagnosis of anemia was based on HB levels and on MCV readings as ferritin levels were not done routinely.

Ninety percent of our women in the study were not informed about the details of the iron supplement and its benefits, when and how to take it and side effects. They did not know that the daily diet contains a number of substances (e.g., calcium, polyphenols, and phytates) that inhibit the absorption of iron by approximately 40% [20]. Consequently, ferrous iron supplements should be taken between meals, preferably with fruit juice.

Containing vitamin C, which enhances absorption, whereas milk, coffee, and tea inhibit absorption [18][21].All women should be given dietary information to maximize iron intake and absorption, and physicians should give more time to council patients regarding the benefits of iron supplements. Counselling was poor among the population of ladies we looked at, and we as health care providers should allocate more time and the skills to counsel patients about anemia, treatment and the side effects.

From our study, 63% were non-compliant to oral iron supplement and the most common reasons for non-compliance were: nausea (17%) and constipation (13%). So gastrointestinal manifestations are the main factors for non-compliance which led to 37% of our ladies discontinuing treatment. These side-effects may be dose dependent.It is generally considered that  doses ≤ 50–60 mg iron/day generate less side-effects than higher doses and that  iron given in controlled release formulations is better tolerated [4][22][23]. However, the meta-regression analysis shows that there is no statistically significant dose-response effect.

A study of Danish pregnant women evaluated the effect of 20, 40, 60, and 80 mg ferrous iron daily from 18 weeks gestation to delivery. It appeared that a dose of 20 mg ferrous iron was inadequate to prevent iron deficiency in a substantial number of women. However, 40 mg ferrous iron prevented IDA in more than 95% of the women. Furthermore, there were no significant differences in iron status between women taking 40, 60, and 80 mg elemental iron [8].The Iron preparations that are available in our hospital contains 60 mg of elemental iron.

Seventy percent of our pregnant women were taking the supplements daily, 13% were taking it more than once. In the United Kingdom, iron supplements are not given routinely.When the level of ferritin is below 30 microgram/l this should prompt treatment.If ferritin is 70microgram /l this reflects iron stores larger than 500 mg, so there is no need for treatment, [24].In our patients, supplements were given to all patients as ferritin levels were not checked routinely and anemia was common (40% of women at booking).

Twenty five percent (25%) of our patients were anemic at the time of delivery but if they have been treated with iron supplements and they were compliant, then this percentage most likely would have been lower.

As found after analyzing the questionnaire, 15% of anemic mothers have low birth babies defined as less than 1.5KG. A meta-analysis summarizing 48 randomized controlled trials and 44 cohort found that, for each 1 g/L increase in maternal hemoglobin, neonatal birth weight increased by 14.0g (6.8 to 21.8g) [10]so that should let us focus on detecting and preventing anemia especially in the third trimester of  pregnancy.

The Gravidity is an important variable significantly associated with anemia. The risk of anemia increases as the number of pregnancies increases from 3–5pregnancies [24], but it is even common in the women who had less than three pregnancies. This finding is consistent with other studies conducted in SaudiArabia and India, in which they found that increased number of pregnancies and deliveries is positively associated with the high risk of developing anemia.[25,26] This is true among  our patients as most of them are multiparas.

In our study, anemia at booking was found in 40% of our patients compared to the developing countries which is 51% [WHO 2004].  This is really high and all these women should have been checked pre-conceptually. Guidelines are essential to tackle this problem to make sure that the Hb of these ladies is within normal limits before conception.Anemia may be relative (physiological) or absolute [27].This may be due to the low socioeconomic status of some of our patients, this will directly affect the nutritional status and iron stores which as a result will decrease. This might explain the high prevalence of anemia among our pregnant population.

Forty patients received 2 units of blood before delivery with all the risks of blood transfusions, this is mainly because they presented late in pregnancy with low HB. No patient received IV iron in our study group. This is something we need to look at and encourage those ladies to take this treatment.

Most of our patients had IDA based on Hb and MCV results. We need to implement a screening program for IDA. More time needs to be spent with our patients explaining the treatment and the side effects of this treatment. This will ensure and increase the compliance with the medications.

CONCLUSION

Anemia is a common problem among our patients. Guidelines and protocols for the management of anemia in pregnancy should be developed, implemented and audited. The guidelines should consider both the types of oral iron supplements and recommended doses.More time should be spent with our patients explaining the risks of anemia, supplement options and the associated side-effects in order to maximize compliance. Measurement of ferritin has to be part of the routine assessment of all patients with anemia.

Limitation of the study

It’s a retrospective study and the sample size is relatively small.

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